The composition and the form of capsules 1 capsule. Gabapentin 300 mg 400 mg Other ingredients: lac

The current veschestvoGabapentin * (Gabapentin *) Display all forms of production (3) of the capsule (3) Gapentek Capsules 300 mg blister 10 pack carton 5; kodEAN: 5690528159028; LS-001755, 2006-07-07 from Actavis Group hf. (Iceland), producer: Kern Pharma menstrual cycle SL (Spain) Gapentek Capsules 400 mg blister pack 10 pack carton 5; kodEAN: 5690528159035; LS-001755, 2006-07-07 from Actavis Group hf. (Iceland), producer: Kern Pharma SL (Spain) Gapentek Capsules 100 mg blister pack 10 pack carton 5; kodEAN: 5690528159011; LS-001755, 2006-07-07 from Actavis Group hf. (Iceland), producer: Kern Pharma SL (Spain)
Last updated description proizvoditelem15.07.2008 Jump to: Structure and Composition Mode of action Pharmacodynamics Pharmacokinetics Indications menstrual cycle Contraindications Pregnancy and breast-feeding Side acts Interaction Method of implementation and dose overdose Special instructions
Nosological systematization (ICD-10) G40.0 localized (focal) (partial) idiopathic epilepsy and epileptic syndromes with convulsive seizures with a focal beginning G40.1 localized (focal) (partial) symptomatic epilepsy and epileptic syndromes with by ordinary partial menstrual cycle seizures G40.2 The localized (focal) (partial) symptomatic epilepsy and epileptic syndromes with all-encompassing partial convulsive seizures, unspecified R52.9 Pain
The composition and the form of capsules 1 capsule. Gabapentin 300 mg 400 mg Other ingredients: lactose monohydrate, corn starch, talc, gelatin, iron oxide reddish, iron oxide yellow, titanium dioxide, 10 pcs in a blister., a stack of cardboard 5 blisters.
Pharmacological action deystvieFarmakologicheskoe - противоэпилептическое.Фармакодинамика gabapentin menstrual cycle structurally similar to the neurotransmitter GABA but its mechanism of actions different from other drugs that interact with GABA-receptors (valproate, menstrual cycle barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists and prodrugs GABA). He does not have the qualities of GABAergic and has no effect on GABA metabolism and seizure. Preliminary studies have shown that gabapentin is associated with α2-δ-subunit voltazhzavisimyh calcium channels menstrual cycle and reduces the flow of calcium ions, which plays an important role in the emergence of neuropathic pain. Other mechanisms of actions of gabapentin menstrual cycle for neuropathic pain are: glutamatzavisimoy menstrual cycle decrease in neuronal death, increase the synthesis of GABA, inhibition of monoamine neurotransmitter release. Gabapentin in clinically significant concentrations did not bind to other sensors, including sensors GABAA, GABAB, benzodiazepine, glutamate, glycine, or N-methyl-d-aspartate. Unlike phenytoin and carbamazepine, gabapentin is not interact with sodium channels in vitro. Gabapentin partially attenuated the effects of glutamate receptor agonist N-methyl-d-aspartate in some tests in vitro, but only at concentrations greater than 100 micromoles, which is not achieved in vivo. Gabapentin slightly reduces the release of monoamine neurotransmitters in vitro.
Bioavailability Pharmacokinetics is not proportional to the dose of gabapentin, so by increasing the dose is reduced. After oral administration of gabapentin Cmax in plasma is reached after 2-3 hours absolute bioavailability of gabapentin capsules is approximately 60%. The food, including with high content of fat, has no effect on pharmacokinetics. Excretion of gabapentin plasma is best described by a linear model. T1 / 2 of the plasma menstrual cycle is not in a dose dependent manner, with an average 5-7 hours Pharmacokinetics unchanged with repeated use; balanced plasma concentration can be predicted on the basis of a single dose of product. Gabapentin does not actually bound to plasma proteins (<3%) and has a volume of 57.7 liters rassredotachivaniya. It just shows the kidneys unchanged, metabolism menstrual cycle is not exposed. The product does not induce hepatic oxidative enzymes mixed function involved in the metabolism of drugs. Ground menstrual cycle clearance of gabapentin plasma falls, pensioners and patients with impaired renal function. Elimination rate constant, plasma clearance and renal clearance are directly proportional to creatinine clearance. Gabapentin is removed from plasma by hemodialysis. In patients with impaired renal function and patients receiving hemodialysis healing, we recommend a dose adjustment (see "Method of implementation and administration").
as an additional tool in the treatment of partial seizures menstrual cycle with or without secondary generalization in adults and her kids from 3 years old and older (safety and efficacy of adjunctive therapy with gabapentin in children at least 3 years of age have not been established).
Pregnancy and lactation There are no data on the use of the drug in pregnant women because gabapentin should be used during menstrual cycle pregnancy SUP