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Created 07.07.2011 Naltrexone has shown efficacy in the treatment of alcohol dependence. oh However, such symptoms as insomnia and mood instability are the most common manifestations of relapse after (drinking bouts). Gabapentin may reduce the symptoms and help prevent relapses. A clinical study conducted under the direction of Dr. Raymond F. Anton, Medical University of South Carolina (USA) showed that the combination of naltrexone with gabapentin is more effective in the treatment of alcohol dependence with naltrexone monotherapy and / or placebo. We examined 150 patients with alcohol dependence who were randomized within 16 weeks of prescribed naltrexone (50 mg per day) or naltrexone (50 mg daily) in combination with gabapentin during the first 6 weeks (1200 mg daily) or placebo . During the first 6 weeks of treatment, patients treated with a combination oh of gabapentin + naltrexone had longer periods of remission than the other groups. Also, patients in this group had a significantly shorter periods of exacerbations. These differences oh remained even after the abolition of gabapentin at 6 weeks of therapy. Thus, the addition of gabapentin oh to naltrexone for 6 weeks improved the prognosis in alcohol dependence, which persists after discontinuation of gabapentin. oh
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