In clinical trials, there was a clear connection between taking Trazodone and gaining weight. In one

Trazodone (Desyrel) is a medication pac that is approved for the treatment of depression. It is classified as an atypical antidepressant that functions as a “SARI” (serotonin antagonist and reuptake inhibitor). In addition to inhibiting the reuptake of serotonin, it also blocks excess serotonin at various receptor sites. It is believed that the combined pac effect of reuptake and antagonism help decrease depression.
The drug has also been found to be beneficial among those with anxiety disorder as well as insomnia. Many doctors pac prescribe Trazodone pac to help those undergoing withdrawal from harder drugs like opioids to help the patient cope with dysphoria and insomnia. Like all antidepressants, Trazodone can have side effects, including that of weight gain. Trazodone and Weight Gain
In clinical trials, there was a clear connection between taking Trazodone and gaining weight. In one study, those who took Trazodone for 6 weeks gained an average of 1.2 pounds. While this may not seem like a striking gain, many people take the drug for a longer duration than 6 weeks, potentially leading to continued weight gain. Many speculate that the weight gained on Trazodone is largely due to its sedating effect and tendency to increase appetite. How Trazodone Causes Weight Gain: List of Possibilities
There are many factors that may contribute to weight gain on Trazodone. These include things like appetite changes, sedation, and slowed baseline metabolism. Keep in mind that these are only possibilities and aren’t necessarily proven. Appetite increase : Many antidepressants have the potential to change a person’s appetite. Some people with depression don’t eat adequate amounts of food. When an antidepressant pac starts working, they realize that they should eat, and they gain some weight. Others believe the appetite increase has to do with neurochemical alterations being made by the drug and that even those who were eating properly prior to taking the medication may develop pac a bigger appetite. Carbohydrate cravings : Some claim that Trazodone makes them crave carbohydrates. While this isn’t proven, it is possible that a medication pac functioning as a serotonin antagonist and reuptake inhibitor could increase carbohydrate cravings. Scientists know that there are clear links between serotonin production and eating carbohydrates. If you notice that you’re seeking out sugary foods, junk foods, and pastas – it could be due to taking this drug. Drug interaction : Anyone who is taking another medication in addition to Trazodone may not realize that the two drugs may interact. In some cases, drugs interact synergistically to amplify a particular side effect like weight gain. Therefore if you are on another medication, it is possible that both are influencing you to pack on weight. Fat storage : Some speculate that it is possible for the body’s fat-storage mechanisms to get altered when a person takes a drug. There is clear evidence for this as a result pac of taking antipsychotic pac medications. Trazodone may disrupt your body’s homeostatic processes, which may result in more fat storage than usual. Hormone levels : Those who take this drug for an extended duration are more likely to experience drug-induced hormone changes. The changes pac in hormones may be subtle and gradual, but they can result in very real changes in weight. While this hasn’t been proven, many self-reports indicate that antidepressants “mine” certain pac hormones, pac making it easier pac to gain weight. Improved taste : When certain people get depressed, food doesn’t seem to taste very good. When they become less depressed, they often experience an improved taste. In other words, things start to taste good again, leading them to eat full meals and seek out food. When this improved taste is coupled with an increased appetite, it makes it very easy to gain weight. Motivational deficit : Some individuals may react to this drug by experiencing pac a drop in motivation. They may feel better or have their insomnia under control, but their motivation may plummet as a result of using Trazodone. This is largely due to the depressant pac effect the drug has on the nervous system. Sedation : Trazodone is considered to be a relatively sedating antidepressant, which is why it’s often prescribed for insomnia. The sedation alone may be responsible for some degree of weight gain. If you take it and feel more sedated than usual, you may have a tough time getting as much physical exercise, which will reduce your metabolism. Side effects : Other side effects from the medication can include sleepiness, fatigue, and feelings of tiredness. Those who experience fatigue and/or increased pac sleepiness will have a tough time getting pac sufficient exercise. They may become increasingly lazy because it’s too difficult to overcome the drug-induced lethargy. In some ways, the side effects can indirectly cause a person to experienc